Addiction and Psychiatric Care

Spravato (esketamine) Treatment

Most Insurances Accepted
Please confirm coverage by calling your Insurance

F.A.Q.

What are the conditions that may be treated with Spravato?

SPRAVATO®, the only FDA-approved nasal spray for adults with treatment-resistant depression, reduces depression symptoms when two or more oral antidepressants haven’t worked.
SPRAVATO® can be taken with or without an oral antidepressant. SPRAVATO® reduces depression symptoms when oral antidepressants haven’t worked:

• SPRAVATO® works differently by acting on glutamate
• Glutamate is a chemical messenger found in the brain that is thought
to help balance well-being and depression
• The exact way SPRAVATO® works is unknown

What are the possible side effects of SPRAVATO®?

SPRAVATO® may cause serious side effects, including sleepiness (sedation), fainting, dizziness, spinning sensation, anxiety, or feeling disconnected from yourself, your thoughts, feelings, space and time (dissociation), and breathing problems (respiratory depression and respiratory arrest).

The Most Common Side Effects of SPRAVATO®:
• feeling anxious
• lack of energy
• increased blood pressure
• feeling disconnected from yourself, your thoughts, feelings and things around you
• vomiting
• feeling drunk
• headache
• feeling very happy or excited
• dizziness
• nausea
• feeling sleepy
• spinning sensation
• decreased feeling of sensitivity (numbness)
If these common side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.

What happens on your first day of treatment?

You will administer SPRAVATO® nasal spray yourself under the supervision of a healthcare provider at a certified
SPRAVATO® treatment center.  

  • After you administer SPRAVATO®, there will be an observation period of at least 2 hours, during which you will rest comfortably while a healthcare provider at the treatment center monitors you for possible side effects.
  • Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery, or do anything where you need to be completely alert until the next day, following a restful sleep.

What happens on your first day of treatment?

For the first month, you’ll take SPRAVATO® twice per week, then once per week for the second month. After that, you and your provider will determine if treatment should be continued and will have the flexibility to decide your treatment frequency.

Can SPRAVATO® help with depression symptoms in adults with MDD with suicidal thoughts or actions (MDSI)?

In clinical studies of adults with MDSI, those who took SPRAVATO® and an oral antidepressant experienced a greater reduction of depression symptoms at 24 hours compared with those who received a placebo plus an oral antidepressant.